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While offering the potential to support learning interactions, emerging AI applications like Large Language Models (LLMs) come with ethical concerns. Grounding technology design in human values can address AI ethics and ensure adoption. To this end, we apply Value‐Sensitive Design—involving empirical, conceptual and technical investigations—to centre human values in the development and evaluation of LLM‐based chatbots within a high school environmental science curriculum. Representing multiple perspectives and expertise, the chatbots help students refine their causal models of climate change's impact on local marine ecosystems, communities and individuals. We first perform an empirical investigation leveraging participatory design to explore the values that motivate students and educators to engage with the chatbots. Then, we conceptualize the values that emerge from the empirical investigation by grounding them in research in ethical AI design, human values, human‐AI interactions and environmental education. Findings illuminate considerations for the chatbots to support students' identity development, well‐being, human–chatbot relationships and environmental sustainability. We further map the values onto design principles and illustrate how these principles can guide the development and evaluation of the chatbots. Our research demonstrates how to conduct contextual, value‐sensitive inquiries of emergent AI technologies in educational settings. Practitioner notesWhat is already known about this topicGenerative artificial intelligence (GenAI) technologies like Large Language Models (LLMs) can not only support learning, but also raise ethical concerns such as transparency, trust and accountability.Value‐sensitive design (VSD) presents a systematic approach to centring human values in technology design.What this paper addsWe apply VSD to design LLM‐based chatbots in environmental education and identify values central to supporting students' learning.We map the values emerging from the VSD investigations to several stages of GenAI technology development: conceptualization, development and evaluation.Implications for practice and/or policyIdentity development, well‐being, human–AI relationships and environmental sustainability are key values for designing LLM‐based chatbots in environmental education.Using educational stakeholders' values to generate design principles and evaluation metrics for learning technologies can promote technology adoption and engagement. 

Abstract Cancer is an umbrella term that includes a wide spectrum of disease severity, from those that are malignant, metastatic, and aggressive to benign lesions with very low potential for progression or death. The ability to prognosticate patient outcomes would facilitate management of various malignancies: patients whose cancer is likely to advance quickly would receive necessary treatment that is commensurate with the predicted biology of the disease. Former prognostic models based on clinical variables (age, gender, cancer stage, tumor grade, etc.), though helpful, cannot account for genetic differences, molecular etiology, tumor heterogeneity, and important host biological mechanisms. Therefore, recent prognostic models have shifted toward the integration of complementary information available in both molecular data and clinical variables to better predict patient outcomes: vital status (overall survival), metastasis (metastasis-free survival), and recurrence (progression-free survival). In this article, we review 20 survival prediction approaches that integrate multi-omics and clinical data to predict patient outcomes. We discuss their strategies for modeling survival time (continuous and discrete), the incorporation of molecular measurements and clinical variables into risk models (clinical and multi-omics data), how to cope with censored patient records, the effectiveness of data integration techniques, prediction methodologies, model validation, and assessment metrics. The goal is to inform life scientists of available resources, and to provide a complete review of important building blocks in survival prediction. At the same time, we thoroughly describe the pros and cons of each methodology, and discuss in depth the outstanding challenges that need to be addressed in future method development. 

Abstract Metabolite profiling is a powerful approach for the clinical diagnosis of complex diseases, ranging from cardiometabolic diseases, cancer, and cognitive disorders to respiratory pathologies and conditions that involve dysregulated metabolism. Because of the importance of systems-level interpretation, many methods have been developed to identify biologically significant pathways using metabolomics data. In this review, we first describe a complete metabolomics workflow (sample preparation, data acquisition, pre-processing, downstream analysis, etc.). We then comprehensively review 24 approaches capable of performing functional analysis, including those that combine metabolomics data with other types of data to investigate the disease-relevant changes at multiple omics layers. We discuss their availability, implementation, capability for pre-processing and quality control, supported omics types, embedded databases, pathway analysis methodologies, and integration techniques. We also provide a rating and evaluation of each software, focusing on their key technique, software accessibility, documentation, and user-friendliness. Following our guideline, life scientists can easily choose a suitable method depending on method rating, available data, input format, and method category. More importantly, we highlight outstanding challenges and potential solutions that need to be addressed by future research. To further assist users in executing the reviewed methods, we provide wrappers of the software packages at https://github.com/tinnlab/metabolite-pathway-review-docker.